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Emerging Gene-Targeting Therapies for SOD1-ALS

Emerging Gene-Targeting Therapies for SOD1-ALS

Reading Time: 5 minutes Last Thursday marked an exciting milestone in the search for effective therapies for MND as full results from the early-phase 1/2 trial of Biogen’s tofersen antisense oligonucleotide therapy for SOD1-ALS were published in The New England Journal of Medicine. In the same issue, a study investigating the use of microRNA in a viral vector to…

Targeting Tregs: IMODALS study paves the way for MIROCALS

Targeting Tregs: IMODALS study paves the way for MIROCALS

Reading Time: 4 minutes Although ALS is a neurodegenerative disease, researchers are increasingly also interested in events happening outside the brain and spinal cord, in particular whether changes in the immune system might play a role in influencing the course of the disease. This is a subject we’ve covered before, with particular reference to the ongoing MIROCALS drug trial…

Panic at the (Cell’s) Depot

Panic at the (Cell’s) Depot

Reading Time: 5 minutes Guest researcher blog post written by Sam Bryce-Smith – sharing his research into changes in ‘post-code’ sequences of RNA, how it continues during the COVID-19 pandemic, and the importance of his funding. We are extremely grateful for the support of the London Freemasons, who are generously supporting one of our new PhD Studentships held by…

Identifying potential new diagnostic biomarkers in the blood

Reading Time: 6 minutes Guest researcher blog post about the recently published paper on the identification of potential new biomarkers in the blood, in the journal Brain Communications. Written by lead author, Dr Greig Joilin, Postdoctoral Research Fellow at the University of Sussex: Diagnosis of MND is currently a time-consuming process of elimination, causing patients and families prolonged stress…

Rapid development of the Telehealth in MND (TiM) Platform

Rapid development of the Telehealth in MND (TiM) Platform

Reading Time: 3 minutes Guest researcher blog post written by Liam Knox: My name is Liam Knox and I am a Postdoctoral Research Associate who has recently joined Dr Esther Hobson and Prof. Chris McDermott (consultant neurologists) on the Telehealth in Motor Neuron Disease, or ‘TiM’ for short, project at the Sheffield Institute for Translational Neuroscience (SITRaN).

Students support MND research awareness with a conference

Students support MND research awareness with a conference

Reading Time: 5 minutes Soon after 8 medical students at the University of Southampton volunteered for the Motor Neurone Disease Association (with their local Southampton and Winchester branch) and created an MND Association MedSoc group at the University, they decided to organise an MND conference in February 2020 to raise interest amongst medical students and other healthcare professionals. Among…