Science behind the picture – Genetics and Genomics

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Manhattan skyline
Manhattan skyline

The picture of the New York skyline is our representation of the ‘manhattan plots’ that are likely to be a feature of Session 7A of the symposium. Unravelling the genetic contribution to MND is as much about maths as it is about DNA. A common type of genetic analysis (known as a ‘GWAS’) compares DNA samples from 1,000s people with MND vs 1,000s of controls. If there is a genetic variation that’s different between these two groups, the bigger the difference, the higher up the ‘dot’ appears on the chart – or in the case of the Manhattan skyline, the higher the skyscraper! Will any hits the scientific equivalent of the Chrysler Building be found? 

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