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Using DNA Bank samples to create iPSC models of MND

Reading Time: 2 minutes Induced pluripotent stem cell (iPSC) technology has enabled researchers to create and study living human motor neurones in the lab, derived originally from patient skin cells. This project (our reference 80-970-797) is a collaboration between the labs of Professors Chris Shaw and Jack Price at King’s College in London and Siddharthan Chandran in Edinburgh. It…

Correcting the early damage seen in MND

Reading Time: 2 minutes Previous research in humans and zebrafish has shown that before symptoms arise in MND, early changes occur in the interneurones. This type of nerve cell provide a link between the upper and lower motor neurones in the brain and spinal cord. The job of one type of interneurone (called inhibitory interneurones) is to apply the…

Developing models to test new treatments for MND

Reading Time: 2 minutes Developing disease models is important for furthering our understanding of MND and allows researchers to screen potential new drugs for a beneficial effect. Moving a promising ‘nearly drug’ from the lab to being tested in people is known as ‘translational research’. Dr Richard Mead was awarded the Kenneth Snowman/MND Association Lectureship in Translational Neuroscience in…