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How animals are helping to improve our understanding of MND

How animals are helping to improve our understanding of MND

Reading Time: 6 minutes ‘From antibiotics and insulin to blood transfusions and treatments for cancer or HIV, virtually every medical achievement in the past century has depended directly or indirectly on research using animals’ – from the Royal Society’s position statement on the use of animals in research. We know that talking about using animals in research is an…

The effects of ashwagandha in a SOD1 mouse model of MND

Reading Time: 2 minutes The research team frequently gets asked about the effectiveness of alternative therapies and their use as treatments for MND. Here we report on a recent paper that looked at the effects of ashwagandha, or Indian ginseng, in a SOD1 mouse model of MND. For around 3000 years Withania somnifera (WS), commonly known as ashwagandha or Indian ginseng,…

Using DNA Bank samples to create iPSC models of MND

Reading Time: 2 minutes Induced pluripotent stem cell (iPSC) technology has enabled researchers to create and study living human motor neurones in the lab, derived originally from patient skin cells. This project (our reference 80-970-797) is a collaboration between the labs of Professors Chris Shaw and Jack Price at King’s College in London and Siddharthan Chandran in Edinburgh. It…

Can zebrafish help us to learn more about MND?

Reading Time: 2 minutes A team at the Sheffield Institute for Translational Neuroscience are creating a zebrafish model to study the C9orf72 gene mutation in MND, and work out its role in the brain and spinal cord (our reference 864-792). Zebrafish are a good way of modelling what happens in human MND. We know that many of the genes…