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4 MND clinical trial updates to end 2022

4 MND clinical trial updates to end 2022

Reading Time: 6 minutes Over the last year ALS/MND clinical trials have taken centre stage, with more trials than ever opening for recruitment in the UK, the news of promising results from some trials and the approval of drugs by some regulatory authorities. With the year coming to an end, we thought we would roundup some recent clinical trial updates that were presented at the 33rd International Symposium on ALS/MND.

Could evidence of MND be found years before the development of physical symptoms?

Could evidence of MND be found years before the development of physical symptoms?

Reading Time: 6 minutes A recent paper (October 2022), published in the journal Journal of Pathology: Clinical Research suggests that evidence of MND can be seen inside people years before they develop physical symptoms. The paper titled ‘pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies…

New discovery reveals why mysterious genetic variant impacts ALS severity

New discovery reveals why mysterious genetic variant impacts ALS severity

Reading Time: 4 minutes My name is Oscar Wilkins and I am a PhD student working with Professors Pietro Fratta (recipient of a MND Association Research Fellowship) and Jernej Ule. Recently, in collaboration with Sarah Hill and Michael Ward, a team led by PhD student Anna-Leigh Brown, postdoctoral researcher Matt Keuss and myself uncovered a promising new target for…