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Physical exercise as a risk factor for MND – is it in our genes?

Physical exercise as a risk factor for MND – is it in our genes?

Reading Time: 5 minutes A potential link between exercise and MND has long been a topic of conversation and debate. Several studies have been carried out, but the discovery of a link has not been conclusively shown. Some have shown an association, but it is important to note that association is very different from cause. Studies that use questionnaire-based…

Should routine genetic testing be considered for all cases of MND?

Should routine genetic testing be considered for all cases of MND?

Reading Time: 9 minutes A paper arising from research carried out at the University of Sheffield as part of the AMBRoSIA biobank, and in collaboration with the international Project MinE gene-hunting consortium, was recently published in the Journal of Neurology, Neurosurgery and Psychiatry. Researchers propose that a test for the most common MND genes could be offered to all…

Does the glymphatic system play a role in MND?

Does the glymphatic system play a role in MND?

Reading Time: 3 minutes At last year’s International Symposium on ALS/MND in Perth, Australia, Professor Jeffrey Iliff talked about the glymphatic system (C1 in abstract book) – a series of ‘tunnels’ containing cerebrospinal fluid (CSF) that distributes nutrients and removes waste from the central nervous system. Prof. Iliff’s team demonstrated that the glymphatic system fails both in the ageing…

Studentship success – next steps for Matthew Nolan

Studentship success – next steps for Matthew Nolan

Reading Time: 5 minutes Guest researcher blog post written by Matthew Nolan. My name is Matthew, I’m currently a post-doctoral researcher at Massachusetts General Hospital and Harvard Medical School in the USA, supported by a Cullen Education and Research Young Investigator Award. Last year I finished my MND Association-funded PhD at the University of Oxford, where I was supervised by…

Toxicity of cerebrospinal fluid in ALS/MND

Toxicity of cerebrospinal fluid in ALS/MND

Reading Time: 4 minutes A systematic review of existing scientific literature, performed by a team of researchers led by Dr Arpan Mehta, MRC/MND Association Lady Edith Wolfson Clinical Fellow based at the Euan MacDonald Centre, University of Edinburgh, supports the view that cerebrospinal fluid obtained from patients with ALS/MND is toxic to cells.  This finding could help to establish…

The FUS with faulty mitochondria – the powerhouse of the cell

The FUS with faulty mitochondria – the powerhouse of the cell

Reading Time: 3 minutes Guest researcher blog post written by Darija Šoltić. Originally from Croatia, I came to the UK to do my PhD in neuroscience, where I worked on spinal muscular atrophy, a debilitating childhood motor neuron disease (MND). Earlier this year, I joined the Ruepp group (led by Dr Marc-David Ruepp) at the UK Dementia Research Institute…