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Symposium Spotlight: A patient fellows perspective

29 June 202329 June 2023Research Development Team

Reading Time: 6 minutes Every year the Patient Fellows Symposium Programme helps people living with MND, from all over the world, to participate in the International Symposium on ALS/MND. The is the largest annual gathering of MND researchers and healthcare professionals dedicated to MND research in the global calendar. Attending provides, those who the research will benefit, an opportunity to have a firsthand view of the most recent and promising research being undertaken by researchers across the world.

EXPERTS-ALS: a new drug testing platform from the UK MND Research Institute

21 June 202321 June 2023Eleanor Green

Reading Time: 6 minutes MND is a very complex disease, and in the UK there is still only one approved treatment so the need for more effective treatments remains at the forefront of MND research. There have been over 140 clinical trials for MND over the last several decades and the majority of these have, unfortunately, not led to…

One hundred not out: keeping up the momentum of MND Research

9 March 20239 March 2023Eleanor Green

Reading Time: 5 minutes Research into MND has increased over recent years and we now have a greater understanding of what is happening within the body during the disease. Only by understanding what is happening within the cells during the disease, will researchers discover the right targets to hit in the development of potential treatments. There is still a…

Do levels of lipids in the body contribute to ALS?

23 February 202324 February 2023Research Development Team

Reading Time: 4 minutes A recent paper published in Brain Communications has identified several lipid (fat-like) molecules that are elevated in MND, specifically amyotrophic lateral sclerosis (ALS) which is the most common form of MND. The study measured the levels of lipids in the blood of people living with ALS and how their lipid levels changed with time during…

Building the MND Research Workforce

10 February 20236 March 2023Emma Williams

Reading Time: 4 minutes The exact causes of MND are still unknown and there remain gaps in knowledge which need filling to find effective treatments. It is like a puzzle with thousands of pieces: some big, some small and some still missing from the box. As decades of research have gone on, the bigger picture continues to become clearer.…

Can signs of MND be detected before symptoms appear?

6 January 20236 January 2023Eleanor Green

Reading Time: 6 minutes It has been suggested that there might be a pre-symptomatic stage of MND, where the disease is active and occurring within a person but no symptoms are showing. There is currently little research in this area and a lack of evidence of a pre-symptomatic stage of the disease. However, if it can be shown that there is a pre-symptomatic stage which can be measured, this could be very useful in helping people with MND to get treatment as early as possible. Dr Michael Benatar, from the University of Miami, has been looking into this by studying the development of MND and how the disease presents in people who have a high risk of developing it.

4 MND clinical trial updates to end 2022

7 December 202213 December 2022Research Development Team

Reading Time: 6 minutes Over the last year ALS/MND clinical trials have taken centre stage, with more trials than ever opening for recruitment in the UK, the news of promising results from some trials and the approval of drugs by some regulatory authorities. With the year coming to an end, we thought we would roundup some recent clinical trial updates that were presented at the 33rd International Symposium on ALS/MND.

Breaking down the MIROCALS clinical trial results

6 December 202222 September 2023Charlotte Roy

Reading Time: 5 minutes The top-line results of the Modifying Immune Response and OutComes in ALS (MIROCALS) clinical trial were announced on 6 December 2022 at the 33rd International Symposium on ALS/MND. As part of the clinical trials session, the scientific leads Dr Gilbert Bensimon and Professor Nigel Leigh discussed the study design and outcomes (C03). MIROCALS was an 18-month,…

Cells behaving badly: what’s going wrong in immune cells in MND?

2 December 20222 December 2022Eleanor Green

Reading Time: 5 minutes A recent paper published in the Journal Neurology: Neuroimmunology & Neuroinflammation has revealed new insights into how immune cells behave in MND. This work, which is the result of a collaboration between researchers across different universities, aimed to uncover more about the role of the immune system in MND progression. The study used blood samples…

Symposium Blogathon: Focus on… Plenary Speakers (Part 2)

8 November 202218 November 2022Charlotte Roy

Reading Time: 7 minutes This blog is part of our Symposium Blogathon series – where we are counting down to the 33rd International Symposium. Numbers in bold blue type correspond to the code in the abstract book. Click on the number to be redirected to the full abstract. Every year, one of the highlights of the Symposium is our…