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Tag: C9ORF72

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Dr Arpan mehta
Causes and disease mechanisms MND Research Research we fund

11th Lady Edith Wolfson Clinical Fellowship awarded

24 July 20175 May 2022

Reading Time: 2 minutesWe are delighted to announce that Dr Arpan Mehta has been appointed as our latest Lady Edith Wolfson Fellow, jointly funded by the MND Association

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Causes and disease mechanisms MND Research

Closing the door on toxic proteins – new clues in understanding a genetic form of MND

5 July 201720 May 2020

Reading Time: 3 minutesThe defects in the C9orf72 gene are known to cause motor neurone disease, but researchers don’t understand why. Defective copies of this gene are passed

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MND Research

Life of an MND researcher – part 2: PhD edition

26 June 20175 May 2022

Reading Time: 4 minutesEach year, the MND Association dedicates the month of June to raising MND awareness. This year, we focus on the eyes – in most people

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MND Research Models of MND Research we fund

Using stem cell technology to understand more about how MND and FTD develop

26 October 201629 April 2022

Reading Time: 3 minutesThe MND Association are funding Prof Kevin Talbot, Dr Ruxandra Dafinca (née Mutihac) and colleagues at the University of Oxford, who are investigating the link

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Causes and disease mechanisms MND Research Research we fund

How faulty proteins disrupt waste recycling and disposal inside nerve cells

1 July 201629 April 2022

Reading Time: 2 minutesResearchers from the Sheffield Institute for Translational Neuroscience (SITraN) at the University of Sheffield have uncovered a new function of the C9orf72 protein. A paper

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Causes and disease mechanisms MND Research Research we fund

Transforming skin cells into nerve cells to understand MND gene mutations

27 June 201629 April 2022

Reading Time: 2 minutesIn previous research Prof Kevin Talbot and colleagues at the University of Oxford began to understand more about how the C9orf72 gene defect causes human

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MND Research Models of MND Research we fund

Investigating C9orf72 and TDP-43 proteins in a fruitfly model of MND

17 June 201629 April 2022

Reading Time: 2 minutesBackground to C9orf72 toxicity We know that damage to C9orf72 (both the gene and the protein it makes) is a crucial step in why some

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MND Research Models of MND Research we fund

Can zebrafish help us to learn more about MND?

16 June 201629 April 2022

Reading Time: 2 minutesA team at the Sheffield Institute for Translational Neuroscience are creating a zebrafish model to study the C9orf72 gene mutation in MND, and work out

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Causes and disease mechanisms MND Research Research we fund

Understanding more about how the cell’s batteries are affected in MND

5 June 201629 April 2022

Reading Time: < 1 minutePhD student Emma Smith has recently started the second year of her MND Association-funded research project at the Sheffield Institute for Translational Neuroscience (SiTRAN) in

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Causes and disease mechanisms MND Research Research we fund

The role of the protein TDP-43 in MND due to C9orf72 mutations

3 June 201629 April 2022

Reading Time: 2 minutesMistakes in the C9orf72 gene are the most common cause of inherited MND, and can be linked to about 40% of all cases. Now that

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