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Transforming skin cells into nerve cells to understand MND gene mutations

Reading Time: 2 minutes In previous research Prof Kevin Talbot and colleagues at the University of Oxford began to understand more about how the C9orf72 gene defect causes human motor neurones to die. These studies were carried out using an impressive piece of lab technology, called induced pluripotent stem cell (iPSC) technology. iPSC technology allows skin cells to be…

Using DNA Bank samples to create iPSC models of MND

Reading Time: 2 minutes Induced pluripotent stem cell (iPSC) technology has enabled researchers to create and study living human motor neurones in the lab, derived originally from patient skin cells. This project (our reference 80-970-797) is a collaboration between the labs of Professors Chris Shaw and Jack Price at King’s College in London and Siddharthan Chandran in Edinburgh. It…

On the fourth day of Christmas MND research gave to me: a new stem cell research project

Reading Time: < 1 minute “On the fourth day of Christmas MND research gives to you… on the FOURTH month of 2014, we announced that we’ll fund an exciting new stem cell project” During our April Biomedical Research Advisory Panel Meeting we agreed to fund seven new MND research projects. These projects included Prof Linda Greensmith’s research on Restoring muscle…

A taste of Brussels…

Reading Time: 3 minutes On 4 November, we welcomed two of our funded researchers to our offices in Northampton. Ruxandra Mutihac and Matt Gabel gave us a ‘taste’ of what’s to come for this year’s 25th International Symposium on ALS/MND, by speaking to us about their research. The symposium is the World’s largest MND-specific research conference and is now only two weeks away!

Human Motor Neurones

Reading Time: 2 minutes Dr Jakub Scaber is a Medical Research Council (MRC)/  MND Association Lady Edith Wolfson Clinical Research Fellow who works in Professor Kevin Talbot’s Laboratory at the Oxford University. Like Prof Chandran’s research, Dr Scaber’s fellowship is also investigating stem-cell derived motor neurones, here he blogs about his research. This is an image of motor neurons. But not just…

A stem cell route to the roots of MND

Reading Time: 7 minutes Nina Rzechorzek is based at the University of Edinburgh. In 2012 Nina’s article on Prof Siddharthan Chandran’s research was shortlisted for the Access to Understanding Competition. Here she gives an update on his stem cell research. It was a typical morning – trying to juggle experiments, trying not to make mistakes, trying hard to get…

Using induced pluripotent stem cells to further our understanding of MND

Reading Time: 4 minutes Dr Jakub Scaber from the University of Oxford is our newest Medical Research Council (MRC)/ MND Association Lady Edith Wolfson Clinical Research Fellow. He is investigating how the newly identified C9orf72 gene causes MND in some individuals using induced pluripotent stem (iPS) cell technology. Researchers funded by the Association were amongst the first to create human…