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The FUS with faulty mitochondria – the powerhouse of the cell

The FUS with faulty mitochondria – the powerhouse of the cell

Reading Time: 3 minutes Guest researcher blog post written by Darija Šoltić. Originally from Croatia, I came to the UK to do my PhD in neuroscience, where I worked on spinal muscular atrophy, a debilitating childhood motor neuron disease (MND). Earlier this year, I joined the Ruepp group (led by Dr Marc-David Ruepp) at the UK Dementia Research Institute…

New gene therapy targeting C9orf72-ALS begins Phase 1 clinical trial in the UK

New gene therapy targeting C9orf72-ALS begins Phase 1 clinical trial in the UK

Reading Time: 2 minutes This article was written by Dr Keith Mayl and Dr Ahmad Al Khleifat of King’s College London. Researchers at King’s College Hospital, led by Professor Christopher Shaw, have embarked on the first gene therapy clinical trial for patients affected by a specific genetic form of ALS, the most common type of MND. ALS is a…

Exploring the interaction between TDP-43 and RNA

Reading Time: 3 minutes In light of the upcoming Biomedical Research Advisory Panel meeting happening on Friday 7 April that will discuss which new research projects the MND Association will fund, we are pleased to report on the progress of one of our already-funded researchers. In their three year project, funded by the MND Association, Prof Annalisa Pastore (King’s College London)…

Our Visit to a Brain Bank

Reading Time: 4 minutes Brain banks are a vital resource in MND research. The MRC London Neurodegenerative Diseases Brain Bank was established in 1989. It is part of King’s College London and King’s College Hospital, and is part-funded by the Medical Research Council (MRC). After 18 months of planning, the bank has recently relocated into a bright terracotta building, fit…

Using surface EMG to see if fasciculations can be used as a biomarker for MND

Reading Time: 2 minutes What are fasciculations? When motor neurones in the spinal cord become damaged this makes them electrically unstable, meaning they spontaneously discharge electrical impulses that cause small groups of muscles to contract. These contractions, known as fasciculations, are a common symptom of MND. Research suggests that they might be a good marker of motor neurone health.…

Using DNA Bank samples to create iPSC models of MND

Reading Time: 2 minutes Induced pluripotent stem cell (iPSC) technology has enabled researchers to create and study living human motor neurones in the lab, derived originally from patient skin cells. This project (our reference 80-970-797) is a collaboration between the labs of Professors Chris Shaw and Jack Price at King’s College in London and Siddharthan Chandran in Edinburgh. It…