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Tag: TDP-43

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Causes and disease mechanisms MND Research Models of MND Research we fund

Investigating the role of the cell’s waste disposal systems in TDP-linked MND

17 August 201720 April 2022

Reading Time: 4 minutesIn April 2016, Dr Jackie Mitchell gave a talk at the Regional Conference in Gatwick to explain the aims of her three year MND Association

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Causes and disease mechanisms MND Research

Exploring the interaction between TDP-43 and RNA

5 April 20175 May 2022

Reading Time: 3 minutesIn light of the upcoming Biomedical Research Advisory Panel meeting happening on Friday 7 April that will discuss which new research projects the MND Association will fund,

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MND Research Models of MND Research we fund

Using stem cell technology to understand more about how MND and FTD develop

26 October 201629 April 2022

Reading Time: 3 minutesThe MND Association are funding Prof Kevin Talbot, Dr Ruxandra Dafinca (née Mutihac) and colleagues at the University of Oxford, who are investigating the link

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Causes and disease mechanisms MND Research Research we fund

Transforming skin cells into nerve cells to understand MND gene mutations

27 June 201629 April 2022

Reading Time: 2 minutesIn previous research Prof Kevin Talbot and colleagues at the University of Oxford began to understand more about how the C9orf72 gene defect causes human

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MND Research Models of MND Research we fund

Developing a drug screen using nerve cells from a mouse model of MND

18 June 201629 April 2022

Reading Time: 2 minutesIn a previous research project funded by the MND Association, Prof Kevin Talbot and colleagues from the University of Oxford developed a new TDP-43 mouse

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MND Research Models of MND Research we fund

Investigating C9orf72 and TDP-43 proteins in a fruitfly model of MND

17 June 201629 April 2022

Reading Time: 2 minutesBackground to C9orf72 toxicity We know that damage to C9orf72 (both the gene and the protein it makes) is a crucial step in why some

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MND Research Research we fund Treatments

Flying towards an understanding of TDP-43

13 June 201629 April 2022

Reading Time: 2 minutesIf you looked at the motor neurones of people with MND down the microscope you would see clumps of a protein called TDP-43. Researchers around

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MND Research Research we fund Treatments

Preventing TDP-43 deposits in motor neurones

11 June 201629 April 2022

Reading Time: 2 minutesDeposits of the protein TDP-43 are found within the motor neurones in the majority of cases of MND, and are considered a pathological hallmark of

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Causes and disease mechanisms MND Research Research we fund

The role of the protein TDP-43 in MND due to C9orf72 mutations

3 June 201629 April 2022

Reading Time: 2 minutesMistakes in the C9orf72 gene are the most common cause of inherited MND, and can be linked to about 40% of all cases. Now that

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Causes and disease mechanisms MND Research Research we fund

Understanding and preventing the protein build-up that can cause nerve cells to die

2 June 201629 April 2022

Reading Time: 2 minutesPrior research has already shown that build-up of the protein TDP-43 is found in the majority of cases of MND (irrespective of whether it was

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