Reading Time: 6 minutes MND is a complex disease, and the causes are still not fully understood. Researchers all around the world are working tirelessly on different theories to try to understand more about what causes MND and how to treat it. One theory is that MND is caused by the activation of ancient viruses which are hidden within…
Reading Time: 5 minutes The pace of MND research continues to increase, with more clinical trials underway in the UK, over the last year, than ever before. Adding to this momentum, the clinical platform trial MAGNET (Multi-arm, Adaptive, Group-sequential trial NETwork)has just opened to recruitment in the UK.
Over the last several decades, there have been over 140 clinical trials for MND and unfortunately most of these have not led to effective treatments. More recently, clinical trial design has become more innovative, including the use of platform trials. MAGNET is a platform trial which aims to accelerate the development of new potential treatments for MND by testing multiple drugs simultaneously.
Reading Time: 5 minutes Recent research, led by scientists at the University of Edinburgh and University of Dundee, has identified abnormalities in a type of brain cell called microglia in MND associated with mutations in the C9orf72 gene. It has been suggested for a long time that motor neurons may not be the only type of cell involved in…
Reading Time: 4 minutes A new clinical trial, investigating Dazucorilant, for the treatment of MND is now open for recruitment in the UK. With this trial, there are now 6 clinical trials recruiting in the UK, further highlighting the current momentum in finding potential effective treatments for MND. People living with MND often show signs of over-active adrenal glands,…
Reading Time: 7 minutes On 25th April 2023 Tofersen (now known as Qalsody in the US), a treatment for SOD1 MND was approved by the Food and Drug Administration (FDA) in the United States. The FDA approval in the US is a welcome step forward in the fight against MND and further highlights the commitment and dedication of the…
Reading Time: 6 minutes Recent research, led by Professor Guillaume Hautbergue at the University of Sheffield, has found a potential new method of preventing nerve cell death in the most common genetic form of MND. This new method could, with further studies, lead to the development of a potential therapy for C9orf72 MND, and a type of dementia called…
Reading Time: 5 minutes Last year was a really exciting year for MND clinical trials, with more trials recruiting in the UK than ever before, some promising results being released, and some drugs being approved by certain regulatory authorities. We hope that the momentum will continue this year and want to highlight just some of the updates we are…
Reading Time: 4 minutes Last year was a really exciting year for MND clinical trials, with more trials recruiting in the UK than ever before, some promising results being released, and some drugs being approved by certain regulatory authorities. We hope that the momentum will continue this year and want to highlight just some of the updates we are…
Reading Time: 4 minutes In 2021, the MND Association, the My Name’5 Doddie Foundation and medical research charity LifeArc established a joint fund – the Motor Neuron Disease Translational Fund – to support translational research in motor neurone disease. In January 2023, £1 million was awarded to researchers at University College London (UCL) to progress two promising new therapies,…
Reading Time: 3 minutes When you think of scientific research most people will immediately imagine a laboratory with scientists in white lab coats, however MND research takes many forms. As well as research that looks for effective treatments, it is also important to investigate ways to improve the well-being of people living with MND and their carers/family members.
