Investigating C9orf72 and TDP-43 proteins in a fruitfly model of MND
Reading Time: 2 minutes Background to C9orf72 toxicity We know that damage to C9orf72 (both the gene and the protein it makes) is a crucial step in why some people get MND and why some people get frontotemporal dementia. There are three possible reasons why C9orf72 is toxic. 1) the way the gene is damaged alters how it normally…