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‘Hero’ proteins assemble to stop toxic clumps

‘Hero’ proteins assemble to stop toxic clumps

Reading Time: 5 minutes Much like fictional superheroes who are dedicated to protecting the vulnerable with their supernatural abilities, a newly discovered class of ‘Hero’ proteins with unusual properties can prevent toxic protein aggregation seen in several neurodegenerative disorders, such as MND. This finding may have potential for new treatments and applications in biotechnology.

TDP-43: A protein that lingers on..

Reading Time: 2 minutes MND Association-funded researchers from the University of Liverpool have published results in the prestigious open access journal Proceedings of the National Academy of Science. Under the leadership of Prof Samar Hasnain, the researchers identified that some TDP-43 mutant proteins hang around in the cell longer and become more stable, possibly leading to neurodegeneration in MND. Although…

The C9orf72 mystery begins to unravel even more of its secrets

Reading Time: 4 minutes In 2011 an international team of scientists, including three MND Association-funded researchers, identified the elusive C9orf72 gene located on Chromosome 9. Since this ground-breaking discovery, researchers from around the world have been trying to find a way to open-up and reveal more about this MND-causing gene. Determined to get inside and unravel the secrets behind…