Reading Time: 2 minutesIn a previous research project funded by the MND Association, Prof Kevin Talbot and colleagues from the University of Oxford developed a new TDP-43 mouse
Reading Time: 2 minutesA team at the Sheffield Institute for Translational Neuroscience are creating a zebrafish model to study the C9orf72 gene mutation in MND, and work out
Reading Time: 2 minutesPrevious research in humans and zebrafish has shown that before symptoms arise in MND, early changes occur in the interneurones. This type of nerve cell
Reading Time: 2 minutesDuring the early stages of MND it is proposed that motor neurones are more susceptible to an imbalance of oxygen within the cells, known as
Reading Time: 2 minutesIf you looked at the motor neurones of people with MND down the microscope you would see clumps of a protein called TDP-43. Researchers around
Reading Time: 2 minutesDeveloping disease models is important for furthering our understanding of MND and allows researchers to screen potential new drugs for a beneficial effect. Moving a
Reading Time: 2 minutesDeposits of the protein TDP-43 are found within the motor neurones in the majority of cases of MND, and are considered a pathological hallmark of
Reading Time: 2 minutesWe know that neck weakness can be a difficult symptom to manage in people with MND, and that the current offering of neck collars and
Reading Time: 2 minutesThe MND Association funds several healthcare research projects that aim to improve care and symptom management for people living with MND. One such project is