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Update on the CENTAUR trial: open label extension data

Update on the CENTAUR trial: open label extension data

Reading Time: 3 minutes A centaur was a creature from Greek mythology which was half-man and half-horse. Despite such an unusual appearance such a combination could have its advantages. It seems that another combination may hold promise in the future for people with ALS/MND (see our previous blog). The CENTAUR clinical trial, which tested a combination of two compounds,…

Understanding family experiences of inherited MND: developing a new web resource on Healthtalk.org

Understanding family experiences of inherited MND: developing a new web resource on Healthtalk.org

Reading Time: 4 minutes Guest researcher blog post written by Jade Howard. Hello, my name is Jade Howard and I am a second year PhD student from The Health Services Research Unit at the University of Aberdeen. I am working on a study of families’ experiences of inherited forms of MND, which affect around 5-10% of people with the…

Does the glymphatic system play a role in MND?

Does the glymphatic system play a role in MND?

Reading Time: 3 minutes At last year’s International Symposium on ALS/MND in Perth, Australia, Professor Jeffrey Iliff talked about the glymphatic system (C1 in abstract book) – a series of ‘tunnels’ containing cerebrospinal fluid (CSF) that distributes nutrients and removes waste from the central nervous system. Prof. Iliff’s team demonstrated that the glymphatic system fails both in the ageing…

Studentship success – next steps for Matthew Nolan

Studentship success – next steps for Matthew Nolan

Reading Time: 5 minutes Guest researcher blog post written by Matthew Nolan. My name is Matthew, I’m currently a post-doctoral researcher at Massachusetts General Hospital and Harvard Medical School in the USA, supported by a Cullen Education and Research Young Investigator Award. Last year I finished my MND Association-funded PhD at the University of Oxford, where I was supervised by…

Toxicity of cerebrospinal fluid in ALS/MND

Toxicity of cerebrospinal fluid in ALS/MND

Reading Time: 4 minutes A systematic review of existing scientific literature, performed by a team of researchers led by Dr Arpan Mehta, MRC/MND Association Lady Edith Wolfson Clinical Fellow based at the Euan MacDonald Centre, University of Edinburgh, supports the view that cerebrospinal fluid obtained from patients with ALS/MND is toxic to cells.  This finding could help to establish…

The FUS with faulty mitochondria – the powerhouse of the cell

The FUS with faulty mitochondria – the powerhouse of the cell

Reading Time: 3 minutes Guest researcher blog post written by Darija Šoltić. Originally from Croatia, I came to the UK to do my PhD in neuroscience, where I worked on spinal muscular atrophy, a debilitating childhood motor neuron disease (MND). Earlier this year, I joined the Ruepp group (led by Dr Marc-David Ruepp) at the UK Dementia Research Institute…