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New discovery reveals why mysterious genetic variant impacts ALS severity

New discovery reveals why mysterious genetic variant impacts ALS severity

Reading Time: 4 minutes My name is Oscar Wilkins and I am a PhD student working with Professors Pietro Fratta (recipient of a MND Association Research Fellowship) and Jernej Ule. Recently, in collaboration with Sarah Hill and Michael Ward, a team led by PhD student Anna-Leigh Brown, postdoctoral researcher Matt Keuss and myself uncovered a promising new target for…

Drug discovery and development

Drug discovery and development

Reading Time: 4 minutes This is blog number 17 in our ‘Symposium Blogathon’ – counting down to the 32nd International Symposium on ALS/MND. Numbers in bold green type correspond to the code in the abstract book. Click on the number to be redirected to the full abstract (the page may take a minute to load). Drug discovery can be…

Assessing cognitive change

Assessing cognitive change

Reading Time: 5 minutes This is blog number 8 in our ‘Symposium Blogathon’ – counting down to the 32nd International Symposium on ALS/MND. Numbers in bold green type correspond to the code in the abstract book. Click on the number to be redirected to the full abstract (the page might take a minute to load). Up to half of…

The importance of phenotyping

The importance of phenotyping

Reading Time: 4 minutes This is blog number 5 in our ‘Symposium Blogathon’ – counting down to the 32nd International Symposium on ALS/MND. Numbers in bold green text correspond to the code in the abstract book. Click on the number to be redirected to the full abstract (the page may take a minute to load). The phenotype is the…

Examining the effects of the compound NU-9 in MND mice

Examining the effects of the compound NU-9 in MND mice

Reading Time: 4 minutes A research paper published recently has investigated the effect of a compound called ‘NU-9’ in mice models of MND. Before we go on, it is important to define ‘compound’ in this context. A compound is something that has pharmacological or biological activity that is likely to be therapeutically useful. It serves as a starting point…

Flexible molecules and droplets: researching and targeting RNA-protein complexes in MND

Flexible molecules and droplets: researching and targeting RNA-protein complexes in MND

Reading Time: 6 minutes My name is Tatyana Shelkovnikova, I am an MND Association Lady Edith Wolfson Senior Non-Clinical fellow. I lead my own group at the Medicines Discovery Institute, Cardiff University. I chose to move my fellowship to a drug discovery unit with a strong neuroscience portfolio of projects to be able to stay at the frontier of…