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Physical exercise as a risk factor for MND – is it in our genes?

Physical exercise as a risk factor for MND – is it in our genes?

Reading Time: 5 minutes A potential link between exercise and MND has long been a topic of conversation and debate. Several studies have been carried out, but the discovery of a link has not been conclusively shown. Some have shown an association, but it is important to note that association is very different from cause. Studies that use questionnaire-based…

Examining the effects of the compound NU-9 in MND mice

Examining the effects of the compound NU-9 in MND mice

Reading Time: 4 minutes A research paper published recently has investigated the effect of a compound called ‘NU-9’ in mice models of MND. Before we go on, it is important to define ‘compound’ in this context. A compound is something that has pharmacological or biological activity that is likely to be therapeutically useful. It serves as a starting point…

Flexible molecules and droplets: researching and targeting RNA-protein complexes in MND

Flexible molecules and droplets: researching and targeting RNA-protein complexes in MND

Reading Time: 6 minutes My name is Tatyana Shelkovnikova, I am an MND Association Lady Edith Wolfson Senior Non-Clinical fellow. I lead my own group at the Medicines Discovery Institute, Cardiff University. I chose to move my fellowship to a drug discovery unit with a strong neuroscience portfolio of projects to be able to stay at the frontier of…

Should routine genetic testing be considered for all cases of MND?

Should routine genetic testing be considered for all cases of MND?

Reading Time: 9 minutes A paper arising from research carried out at the University of Sheffield as part of the AMBRoSIA biobank, and in collaboration with the international Project MinE gene-hunting consortium, was recently published in the Journal of Neurology, Neurosurgery and Psychiatry. Researchers propose that a test for the most common MND genes could be offered to all…

Boosting energy in nerve cells is a promising target for MND treatments

Boosting energy in nerve cells is a promising target for MND treatments

Reading Time: 3 minutes A study conducted by researchers at the Euan MacDonald Centre at the University of Edinburgh has shed light on how improving the function of mitochondria – the power supply of nerve cells – could be a potential treatment for motor neurone disease, paper published this week in the journal, Acta Neuropathologica (2021). This study paves…

Virtual Symposium: Through the eyes of an early career MND researcher

Virtual Symposium: Through the eyes of an early career MND researcher

Reading Time: 4 minutes This blog is part of the ‘Virtual Highlights’ collection of articles, where you can read about the content of some of the talks and posters presented at the Virtual 31st International Symposium on ALS/MND. Guest researcher blog post written by Nora Markus, 2019 Symposium Biomedical Poster Prize winner. About me My name is Nora Markus,…

SPiQE – new analytical tool digs deeper into fasciculations

SPiQE – new analytical tool digs deeper into fasciculations

Reading Time: 5 minutes Cristina Cabassi is an honorary research assistant investigating fasciculations in people with MND. In this guest blog she tells us a little about herself and the project she is involved with – SPiQE, which stands for surface potential quantification engine, technology developed to detect activity from a specific type of muscle recording.