Reading Time: 3 minutesIntroduction A genetic change in the C9orf72 gene is the most common genetic cause of motor neurone disease (MND), accounting for 40%-50% of people with
Tag: MND research
Reading Time: 5 minutesThe pace of MND research continues to increase, with more clinical trials underway in the UK, over the last year, than ever before. Adding to this momentum, the clinical platform trial MAGNET (Multi-arm, Adaptive, Group-sequential trial NETwork)has just opened to recruitment in the UK.
Over the last several decades, there have been over 140 clinical trials for MND and unfortunately most of these have not led to effective treatments. More recently, clinical trial design has become more innovative, including the use of platform trials. MAGNET is a platform trial which aims to accelerate the development of new potential treatments for MND by testing multiple drugs simultaneously.
Reading Time: 5 minutesRecent research, led by scientists at the University of Edinburgh and University of Dundee, has identified abnormalities in a type of brain cell called microglia
Reading Time: 5 minutesALS is the most common form of MND and these terms are used interchangeably in this blog. MND is a complex disease, with many potential
Reading Time: 4 minutesA new clinical trial, investigating Dazucorilant, for the treatment of MND is now open for recruitment in the UK. With this trial, there are now
Reading Time: 7 minutesOn 25th April 2023 Tofersen (now known as Qalsody in the US), a treatment for SOD1 MND was approved by the Food and Drug Administration
Reading Time: 4 minutesIt is known that people with MND experience different symptoms, and these are not just movement related. People with MND can experience difficulty speaking, breathing
Reading Time: 4 minutesIt is well known that more men are diagnosed with MND than women. It is not altogether clear exactly why this is the case and
Reading Time: 6 minutesRecent research, led by Professor Guillaume Hautbergue at the University of Sheffield, has found a potential new method of preventing nerve cell death in the
Reading Time: 4 minutesSome people with MND experience severe swallowing difficulties and it is estimated that over 50% of those with MND are affected by malnutrition and weight loss due to this. These factors are thought to be associated with increased disability and shortened survival, which is why nutrition remains one of the main challenges surrounding disease management. For those with MND who have severe swallowing difficulties, one of the long-term nutritional support options is a gastrostomy (a feeding tube that is inserted directly into the stomach to deliver food, fluids and some medications).