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Panic at the (Cell’s) Depot

Panic at the (Cell’s) Depot

Reading Time: 5 minutes Guest researcher blog post written by Sam Bryce-Smith – sharing his research into changes in ‘post-code’ sequences of RNA, how it continues during the COVID-19 pandemic, and the importance of his funding. We are extremely grateful for the support of the London Freemasons, who are generously supporting one of our new PhD Studentships held by…

Identifying potential new diagnostic biomarkers in the blood

Reading Time: 6 minutes Guest researcher blog post about the recently published paper on the identification of potential new biomarkers in the blood, in the journal Brain Communications. Written by lead author, Dr Greig Joilin, Postdoctoral Research Fellow at the University of Sussex: Diagnosis of MND is currently a time-consuming process of elimination, causing patients and families prolonged stress…

Catch up on Symposium…focus on causes and treatments

Reading Time: 8 minutes Following on from our previous catch-up blog on clinical management talks presented at the Symposium, here is a continuation that looks at talks focusing on treatment therapies and causes of MND. RNA Binding & Transport RNA is the lesser-known ‘cousin’ of DNA – it contains copies of genetic instructions sent out from the nucleus –…

Closing the door on toxic proteins – new clues in understanding a genetic form of MND

Reading Time: 3 minutes The defects in the C9orf72 gene are known to cause motor neurone disease, but researchers don’t understand why. Defective copies of this gene are passed down in some families affected by the rare, inherited form of MND. This week MND Association grantees Drs Guillaume Hautbergue, Lydia Castelli and colleagues, based at the Sheffield Institute of…

Exploring the interaction between TDP-43 and RNA

Reading Time: 3 minutes In light of the upcoming Biomedical Research Advisory Panel meeting happening on Friday 7 April that will discuss which new research projects the MND Association will fund, we are pleased to report on the progress of one of our already-funded researchers. In their three year project, funded by the MND Association, Prof Annalisa Pastore (King’s College London)…

Motor neurone signalling and the effects of RNA in MND

Reading Time: 2 minutes Dr Pietro Fratta completed his first MRC-MND Association Clinical Research Training Fellowship in 2014. Last year he was awarded a new £1.16 million Clinician Scientist Fellowship to continue his research at University College London, studying the earliest physical changes that affect motor neurons in MND (our reference 946-795). Our contribution to this four year research…

The MND Researchers Bake off Champion!

Reading Time: 2 minutes As well as helping out with our ‘blog a day’ during MND Awareness Month, we also asked our researchers to get involved in ‘baking’ to become our first ‘MND Researchers Bake off Champion’. We received some great science-themed cakes, from zebrafish biscuits to a Nuclear Magnetic Resonance(NMR) machine cake! Our Director of Research, Dr Brain Dickie said:…

What’s all the ‘FUS’ about?

Reading Time: 3 minutes Prof Vladimir Buchman (Cardiff University)’s research was selected as one of the best research studies, as decided by the journal editors, published in the Journal of Biological Chemistry in 2013. He is building on this research in his Association-funded project, which began on 1 April 2014. The background to FUS: In 2009 an international team…

Of yeast and men: reducing toxic effects of TDP-43 as a potential treatment for MND

Reading Time: 4 minutes A collaborative American research group, led by Prof Aaron Gitler from Stanford University School of Medicine in California, has identified a potential therapeutic target for MND using yeast. The toxic activity of the MND-linked protein TDP-43 was suppressed when a gene called DBR1 was deleted from yeast and mammal cells. The study marks the first…