Reading Time: 7 minutesClinical trials are vital in the hunt for effective treatments of motor neurone disease. They provide the evidence needed to determine whether a drug is
Author: Eleanor Green
I work in the Research Development team at the MND Association as a Senior Research Co-ordinator. I completed my undergraduate degree in Biomedical Science and I became very interested in neuroscience throughout my degree. Following on from this, I did a Master’s degree in Molecular Medicine, with a focus on gene therapies. As part of my role, I identify interesting updates in MND research and communicate these via the blog in an understandable and engaging way.
Reading Time: 5 minutesThe MND clinical trial landscape has grown vastly over the last decade and this has led to increased opportunities for people with MND to take
Reading Time: 6 minutesTo fight motor neurone disease, we need a steady stream of enthusiastic and passionate scientists who can bring new ideas and push boundaries. Often, we
Reading Time: 6 minutesMND is a very complex disease, and in the UK there is still only one approved treatment so the need for more effective treatments remains
Reading Time: 5 minutesThe current pace of clinical trials means that there are now more trials testing potential drugs for MND in the UK than ever before. One
Reading Time: 5 minutesThe pace of MND research continues to increase, with more clinical trials underway in the UK, over the last year, than ever before. Adding to this momentum, the clinical platform trial MAGNET (Multi-arm, Adaptive, Group-sequential trial NETwork)has just opened to recruitment in the UK.
Over the last several decades, there have been over 140 clinical trials for MND and unfortunately most of these have not led to effective treatments. More recently, clinical trial design has become more innovative, including the use of platform trials. MAGNET is a platform trial which aims to accelerate the development of new potential treatments for MND by testing multiple drugs simultaneously.
Reading Time: 4 minutesA new clinical trial, investigating Dazucorilant, for the treatment of MND is now open for recruitment in the UK. With this trial, there are now
Reading Time: 4 minutesIt is known that people with MND experience different symptoms, and these are not just movement related. People with MND can experience difficulty speaking, breathing
Reading Time: 4 minutesSome people with MND experience severe swallowing difficulties and it is estimated that over 50% of those with MND are affected by malnutrition and weight loss due to this. These factors are thought to be associated with increased disability and shortened survival, which is why nutrition remains one of the main challenges surrounding disease management. For those with MND who have severe swallowing difficulties, one of the long-term nutritional support options is a gastrostomy (a feeding tube that is inserted directly into the stomach to deliver food, fluids and some medications).