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31st Symposium: Virtual Causes and disease mechanisms MND Research Research we fund

Flexible molecules and droplets: researching and targeting RNA-protein complexes in MND

16 March 20212 August 2024

Reading Time: 6 minutesMy name is Tatyana Shelkovnikova, I am an MND Association Lady Edith Wolfson Senior Non-Clinical fellow. I lead my own group at the Medicines Discovery

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Causes and disease mechanisms MND Research Research we fund

Panic at the (Cell’s) Depot

23 June 202023 June 2020

Reading Time: 5 minutesGuest researcher blog post written by Sam Bryce-Smith – sharing his research into changes in ‘post-code’ sequences of RNA, how it continues during the COVID-19

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Causes and disease mechanisms MND Research Research we fund

Motor neurone signalling and the effects of RNA in MND

30 June 201629 April 2022

Reading Time: 2 minutesDr Pietro Fratta completed his first MRC-MND Association Clinical Research Training Fellowship in 2014. Last year he was awarded a new £1.16 million Clinician Scientist

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Causes and disease mechanisms MND Research Research we fund

Identifying the genetic causes of MND in specific populations

29 June 201629 April 2022

Reading Time: 2 minutesDr Russell McLaughlin from Trinity College Dublin is one of our Junior Non-Clinical Fellows. Our Non-Clinical Fellowships were awarded for the first time last year.

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Causes and disease mechanisms MND Research Research we fund

Using iPSCs to understand why motor neurones lose their normal function in MND

28 June 20168 April 2022

Reading Time: 2 minutesResearchers can create human motor neurones exhibiting signs of MND in the lab by taking skin cells from a person living with MND and reprogramming

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Causes and disease mechanisms MND Research Research we fund

Transforming skin cells into nerve cells to understand MND gene mutations

27 June 201629 April 2022

Reading Time: 2 minutesIn previous research Prof Kevin Talbot and colleagues at the University of Oxford began to understand more about how the C9orf72 gene defect causes human

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Markers of Disease Progression MND Research Research we fund

Defining disease progression in MND from MRI ‘snapshots’

26 June 201629 April 2022

Reading Time: 2 minutesAlthough conventional brain magnetic resonance imaging (MRI) scans are often normal in people with MND, more sophisticated MRI techniques have shown changes in the structure

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Markers of Disease Progression MND Research Research we fund

Using a new imaging technique to shed light on changes to nerve cells in MND

25 June 201629 April 2022

Reading Time: 2 minutesMagnetic Resonance Imaging (MRI) technology is advancing rapidly as a tool for diagnosing and monitoring disease. In MND, MRI scans are used to understand changes

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Markers of Disease Progression MND Research Research we fund

Using surface EMG to see if fasciculations can be used as a biomarker for MND

24 June 201629 April 2022

Reading Time: 2 minutesWhat are fasciculations? When motor neurones in the spinal cord become damaged this makes them electrically unstable, meaning they spontaneously discharge electrical impulses that cause

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Markers of Disease Progression MND Research Research we fund

Developing ultrasound imaging as a potential non-invasive diagnostic tool for MND

23 June 201629 April 2022

Reading Time: 3 minutesWhen diagnosing MND, it is important to look at the activity and impact of the motor neurones themselves – is the electrical message being carried

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