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Identifying the genetic causes of MND in specific populations

Reading Time: 2 minutes Dr Russell McLaughlin from Trinity College Dublin is one of our Junior Non-Clinical Fellows. Our Non-Clinical Fellowships were awarded for the first time last year. They aim to retain and develop early and mid-career MND researchers conducting biomedical research. These fellowships are funded for up to four years. We are currently funding two junior and…

Transforming skin cells into nerve cells to understand MND gene mutations

Reading Time: 2 minutes In previous research Prof Kevin Talbot and colleagues at the University of Oxford began to understand more about how the C9orf72 gene defect causes human motor neurones to die. These studies were carried out using an impressive piece of lab technology, called induced pluripotent stem cell (iPSC) technology. iPSC technology allows skin cells to be…

Using a new imaging technique to shed light on changes to nerve cells in MND

Reading Time: 2 minutes Magnetic Resonance Imaging (MRI) technology is advancing rapidly as a tool for diagnosing and monitoring disease. In MND, MRI scans are used to understand changes that happen to the brain because of this disease. Prof Nigel Leigh from the Brighton and Sussex Medical School (University of Sussex) is carrying out a study looking into changes…

Working together towards a world free from MND

Reading Time: 4 minutes During MND Awareness Month we are highlighting some of the research the MND Association funds in our ‘Project a Day’ series. Today, on global ALS/MND awareness day, we wanted to give you a look at the research into motor neurone disease taking place elsewhere. Thousands of researchers across the globe are working towards a world…

Developing the Biomarkers in Oxford Project

Reading Time: 2 minutes Biomarkers in Oxford (BioMOx) is a research project with the aim of identifying a diagnostic biomarker for MND, which could be used to track the progression of this condition. What are biomarkers? The aim is to identify biomarkers, or ‘biological fingerprints’ for MND. This could be through testing blood and spinal fluid (CSF) samples from…

Can zebrafish help us to learn more about MND?

Reading Time: 2 minutes A team at the Sheffield Institute for Translational Neuroscience are creating a zebrafish model to study the C9orf72 gene mutation in MND, and work out its role in the brain and spinal cord (our reference 864-792). Zebrafish are a good way of modelling what happens in human MND. We know that many of the genes…