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TDP-43: A protein that lingers on..

Reading Time: 2 minutes MND Association-funded researchers from the University of Liverpool have published results in the prestigious open access journal Proceedings of the National Academy of Science. Under the leadership of Prof Samar Hasnain, the researchers identified that some TDP-43 mutant proteins hang around in the cell longer and become more stable, possibly leading to neurodegeneration in MND. Although…

The cell that never grew up

Reading Time: 4 minutes With Pantomime season kicking off back home in the UK, delegates in Milan were introduced to one of the newest cellular villains in the MND story – oligodendrocytes. Although oligodendrocytes were first identified in the 1920s and are known to be affected in multiple sclerosis, they were generally considered as ‘bit part’ players in MND…

Major new research finding raises some old questions

Reading Time: 3 minutes Hot on the heels of ‘Brain Awareness Week’, comes ‘National Science Week’, with the University of Sheffield enthusiastically organising a numerous activities in their week-long Festival of Science and Engineering, including today’s Open Day at the Sheffield Institute of Translational Neuroscience (SITraN). This event was to include talks by Dr Chris McDermott and Prof Pam…

Share nicely!

Reading Time: 3 minutes The phrase ‘Share nicely’ is one that I associate with children sharing their toys, sweets and perhaps even Wii time. However, it works well in a research context too. A steady momentum has been building of new ways to share, so I wanted to write a post to highlight them. For the last 23 years…

University of Bath research shows how angiogenin affects motor neurone survival

Reading Time: 3 minutes Published in the prestigious journal Nature Communications and funded by the Wellcome Trust, University of Bath researchers looked closely at the structure of 11 mutated angiogenin proteins, and how changes in their structure influenced activity, function and survival in motor neurones. Dr Brian Dickie, Director of Research at the Association, said “The researchers at the…