30 chapters of MND research

During MND Awareness Month (1-30 June), we will be publishing a new post each day. Our ‘Project a Day’ series will celebrate the whole range of areas in which the MND Association funds research.

Thanks to the generous donations of our supporters, we currently fund over 80 research projects, across five themes:

  • Causes: These projects aim to understand what causes the motor neurones to die. This is essential to allow the development of treatments.
  • Models of MND: One way in which to understand the function of a gene and how this goes wrong in disease is to use a model. These projects aim to develop new and better models of MND to understand the causes of MND.
  • Healthcare: These projects aim to increase the quality of life of people living with MND, as well as improving care. These projects have a direct impact on people living with MND here and now.
  • Markers of disease progression: There is currently no diagnostic test for MND and no specific ‘biomarker’ to monitor the disease. These projects aim to find a marker of disease progression to speed up diagnosis, prognosis and disease monitoring of MND.
  • Developing treatments: These projects aim to test the effectiveness of potential treatments, from laboratory stage to the clinical trial environment.

Read More »

Measuring the nerve impulse

Devlin et al (2015)

Researchers identify that loss of nerve signalling may be an early sign of MND

Published in Nature Communications on 12 January 2015, Association-funded PhD student Anna-Claire Devlin, based at the University of St Andrews, has identified that loss of nerve signalling may be an early sign of MND.

Under the leadership of Dr Gareth Miles and Prof Siddharthan Chandran (University of Edinburgh), Anna-Claire measured the nerve impulses in stem cell derived human motor neurones and identified that the ability to send a nerve impulse is impaired during the early stages of the disease. Read More »