Can zebrafish help us to learn more about MND?

A team at the Sheffield Institute for Translational Neuroscience are creating a zebrafish model to study the C9orf72 gene mutation in MND, and work out its role in the brain and spinal cord (our reference 864-792).

Zebrafish are a good way of modelling what happens in human MND. We know that many of the genes linked to causing MND in humans are also found in zebrafish. For example, changes to a gene called SOD-1 in humans are linked to about 20% of all cases of inherited MND, and when you genetically change the same gene in zebrafish they develop symptoms similar to MND.

A faulty or changed C9orf72 gene is associated with about 40% of all cases of the inherited form of MND. This change (or mutation) is also found in people with a form of dementia called frontotemporal dementia (FTD). FTD can alter abilities in decision-making and behaviour.Read More »

An insight into MND zebrafish research

Natalie Rounding is a first year PhD student funded by the MND Association. Based at the Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, she gives us an insight into zebrafish and how they can be used in MND research.

CDBG Aquarium Sheffield (Natlie Rounding)
Image of one the zebrafish aquariums in the MRC Centre for Developmental and Biomedical Genetics, University of Sheffield.

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