Developing models to test new treatments for MND

Developing disease models is important for furthering our understanding of MND and allows researchers to screen potential new drugs for a beneficial effect. Moving a promising ‘nearly drug’ from the lab to being tested in people is known as ‘translational research’.

Dr Richard Mead
Dr Richard Mead

Dr Richard Mead was awarded the Kenneth Snowman/MND Association Lectureship in Translational Neuroscience in May 2014. The Lectureship is part funded by the MND Association (our reference 983-797).

We have recently received a progress report from Dr Mead. Its clear that his background and experience in this area – including several years working in the pharmaceutical industry – has helped him to rapidly develop a portfolio of projects and collaborations with academic and industry partners.Read More »

Collaborating across Europe to find a cure: ENCALS 2016

332 delegates, 135 posters, 41 talks, one goal: to cure ALS

The European Network for the Cure of Amyotrophic Lateral Sclerosis (ENCALS) was set up to find a cure for ALS/MND by working collaboratively across 35 research centres (universities and hospitals) throughout Europe.

The 14th meeting of ENCALS took place in Milan between 19-21 May and was attended by scientists and doctors from across Europe. Researchers from the USA and Canada were also invited to present at this meeting.

Presentations on day one of this year’s meeting looked at some of the techniques to help identify genetic changes (mutations) linked to MND, such as whole genome sequencing. This is a rapidly growing area of research, thanks to Project MinE  – a global effort to find MND causing genes.

Clinical research was the focus on day two, and discussed the latest imaging and biomarker research. This is an important area as it will offer new ways to help track the progression of MND, and help to speed up diagnosis of this disease.Read More »

Cycling to ENCALS – “on yer bike”

Medical Research Council (MRC)/ MND Association Lady Edith Wolfson Clinical Research Fellow, Dr Johnathan Cooper-Knock, is based at the Sheffield Institute for Translational Neuroscience (SITraN), at the University of Sheffield. The Tour de France ends up in Sheffield a week today, so to get you into the cycling spirit, John blogs about the Sheffield to Leuven ENCALS cycling challenge!

The great idea

A few weeks ago Richard Mead and I had a chat in the lab. We wondered whether it would be possible to cycle to Leuven for the forthcoming European Network for a Cure of ALS (ENCALS) conference (22 – 24 May 2014). Well of course it would be possible, but given finite resources, time and training could we do it? When we discovered the overnight ferry from Hull to Zeerbrugge (which we were reliably informed only resulted in sea-sickness 60% of the time) we realised the dream could become a reality. Read More »

New MND Association Lectureship in Translational Neuroscience

Dr Richard Mead based at the Sheffield Institute for Translational Neuroscience (SITraN) at the University of Sheffield has been awarded the Kenneth Snowman-MND Association Lectureship in Translational Neuroscience.

Dr Richard Mead, SITraN, UK
Dr Richard Mead, SITraN, UK

The five-year Kenneth Snowman-MND Association lectureship is aimed to embed preclinical expertise in motor neurone disease (MND) models within SITraN as a national resource.

Our Director of Research Development at the Association, Dr Brian Dickie, commented: “We are delighted to be able to help secure the position of an outstanding young scientist at one of the top European centres for MND research.

“Our understanding of the causes of MND and the reasons why motor neurons degenerate is increasing rapidly and we need more researchers like Dr Mead who are ideally placed to move this new understanding from the laboratory to the clinic.”

Read more about this story on our website: New MND Association Lectureship in Translational Neuroscience.