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MND EnCouRage UK: “One of the early career researchers may hold the cure in their hands. They just don’t know it yet.”

MND EnCouRage UK: “One of the early career researchers may hold the cure in their hands. They just don’t know it yet.”

Reading Time: 6 minutes To fight motor neurone disease, we need a steady stream of enthusiastic and passionate scientists who can bring new ideas and push boundaries. Often, we talk of MND research as a puzzle, with each new piece of research adding to the bigger picture. The scientists just beginning their careers, known as early career researchers, could…

Investigating differences in protein production in MND

Investigating differences in protein production in MND

Reading Time: 4 minutes My name is Dr Hannah Smith, and I’m a post-doctoral researcher at the University of Edinburgh. My project is supervised by Professor Tom Gillingwater, and my work is funded by MND Scotland. My current research focuses on comparing healthy motor neurons and those with MND/ALS, specifically focusing on early changes to the cellular machinery and how the motor neurons produce the proteins they need to function. I’ll discuss the specifics of that, and why we are interested in finding out this information, in the next section.

Growing brain cells in 3D to study MND

Growing brain cells in 3D to study MND

Reading Time: 5 minutes My current work focuses on looking at the cell types that are affected in MND and how they impact each other. Motor neurons, the main cell type affected in MND, connect our brains and muscles. This connection is what allows us to move. In MND, these cells start to die, which is what leads to progressive paralysis. But motor neurons aren’t the only cell types affected by MND. They are surrounded by many more cells called glia, which have roles in keeping our motor neurons healthy.

Improving the protection of motor neurons in MND

Improving the protection of motor neurons in MND

Reading Time: 5 minutes I’m Hannah, an MND Association-funded first year PhD student at the University of Nottingham. During my undergraduate degree in Biochemistry, also at Nottingham, I had the opportunity to do a project researching MND in the lab, where my interest in MND began. During this project I also met someone who was living with MND, who had come to hear about the research happening in our lab. Hearing his insights into the devastating effects of MND really stuck with me, and I decided I wanted to begin a career in MND research. This led me to my PhD project, in which I am aiming to make a natural type of cell called astrocytes more protective of motor neurones. We hope that this work will inform us of a possible new way to treat MND.

Improving the management of cough and secretion problems in MND

Improving the management of cough and secretion problems in MND

Reading Time: 3 minutes My name is Charlotte and I am a specialist physiotherapist who has worked within the field of MND and neuromuscular disease for many years. Prior to starting my PhD, I worked as the lead physiotherapist on the Neuromuscular Complex Care Centre (NMCCC) at the National Hospital for Neurology and Neurosurgery, part of UCL centre for neuromuscular diseases in London.

Investigating the role of FUS in MND

Investigating the role of FUS in MND

Reading Time: 3 minutes My name is Sara Tacconelli and I grew up in a small town in Abruzzo, Italy, and I was raised in a nurturing environment, surrounded by love and affection from my family and friends. I always had a passion for science and as I grew older, a strong desire to dedicate my life to a meaningful cause emerged within me- a desire to somehow make a difference in the lives of others.