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Toxicity of cerebrospinal fluid in ALS/MND

Toxicity of cerebrospinal fluid in ALS/MND

Reading Time: 4 minutes A systematic review of existing scientific literature, performed by a team of researchers led by Dr Arpan Mehta, MRC/MND Association Lady Edith Wolfson Clinical Fellow based at the Euan MacDonald Centre, University of Edinburgh, supports the view that cerebrospinal fluid obtained from patients with ALS/MND is toxic to cells.  This finding could help to establish…

11th Lady Edith Wolfson Clinical Fellowship awarded

11th Lady Edith Wolfson Clinical Fellowship awarded

Reading Time: 2 minutes We are delighted to announce that Dr Arpan Mehta has been appointed as our latest Lady Edith Wolfson Fellow, jointly funded by the MND Association and Medical Research Council.  This clinical research training fellowship will help to launch his career as an aspiring academic neurologist, providing comprehensive training in cellular, molecular and bioinformatics technologies in…

Using DNA Bank samples to create iPSC models of MND

Reading Time: 2 minutes Induced pluripotent stem cell (iPSC) technology has enabled researchers to create and study living human motor neurones in the lab, derived originally from patient skin cells. This project (our reference 80-970-797) is a collaboration between the labs of Professors Chris Shaw and Jack Price at King’s College in London and Siddharthan Chandran in Edinburgh. It…

Giving voice to people living with MND: Voice Banking

Reading Time: 5 minutes Phillipa Rewaj, Rebecca Devon and Shuna Colville from the Euan MacDonald Centre for MND Research, University of Edinburgh, help us celebrate Global MND Awareness day. This year’s theme is ‘voice’ and here the researchers provide us with an update on their pioneering ‘voicebanking project’, which is part-funded by the MND Association.   Ring ring….ring ring….…

A stem cell route to the roots of MND

Reading Time: 7 minutes Nina Rzechorzek is based at the University of Edinburgh. In 2012 Nina’s article on Prof Siddharthan Chandran’s research was shortlisted for the Access to Understanding Competition. Here she gives an update on his stem cell research. It was a typical morning – trying to juggle experiments, trying not to make mistakes, trying hard to get…

Understanding Spinal Muscular Atrophy: could plant derived compounds hold the key?

Reading Time: 4 minutes On 3 March 2014, researchers based at the University of Edinburgh published a research paper that extends our understanding of the childhood disease – Spinal Muscular Atrophy (SMA). Although this is not MND so-to-speak, the disease does affect the motor neurones. Plus, the results were so interesting; I couldn’t resist writing a blog post about them.…

Screening for Cognitive and Behavioural Change in MND

Reading Time: 3 minutes MND Association-funded researcher Dr Sharon Abrahams (University of Edinburgh) has recently published an article on the Edinburgh Cognitive ALS Screen (ECAS) in the prestigious journal Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. It is now recognised that, in up to 50% of people living with MND not only the motor system (walking, talking breathing etc) but also…