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Can zebrafish help us to learn more about MND?

Reading Time: 2 minutes A team at the Sheffield Institute for Translational Neuroscience are creating a zebrafish model to study the C9orf72 gene mutation in MND, and work out its role in the brain and spinal cord (our reference 864-792). Zebrafish are a good way of modelling what happens in human MND. We know that many of the genes…

Flying towards an understanding of TDP-43

Reading Time: 2 minutes If you looked at the motor neurones of people with MND down the microscope you would see clumps of a protein called TDP-43. Researchers around the world are working to find why these clumps form and how they are linked to MND. Dr Jemeen Sreedharan has been looking at the effects of TDP-43 in fruit…

Pretty ‘fly’ for a fruit fly

Reading Time: 4 minutes Dr Frank Hirth is one of the world’s leading fruit fly MND researchers. Based at the Institute of Psychiatry, Psychology and Neuroscience at King’s College London, he has been working on an Association-funded project developing a C9orf72 fruit fly model of MND. Here we mark the end of this project, and report on what the researchers…

Switching the light on for MND

Reading Time: 4 minutes MND Association-funded researcher, Prof Linda Greensmith, based at University College London, together with her collaborator Dr Ivo Lieberam from Kings College London, have introduced stem cell-derived motor neurones into mice. Published in the prestigious journal Science on 4 April 2014, her research has also demonstrated that muscle function can be controlled by light. Modelling MND…