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Investigating differences in protein production in MND

19 October 202319 October 2023Research Development Team

Reading Time: 4 minutes My name is Dr Hannah Smith, and I’m a post-doctoral researcher at the University of Edinburgh. My project is supervised by Professor Tom Gillingwater, and my work is funded by MND Scotland. My current research focuses on comparing healthy motor neurons and those with MND/ALS, specifically focusing on early changes to the cellular machinery and how the motor neurons produce the proteins they need to function. I’ll discuss the specifics of that, and why we are interested in finding out this information, in the next section.

ANQUR: A new clinical trial in the UK for MND

7 September 20237 September 2023Eleanor Green

Reading Time: 6 minutes QurAlis, a biotechnology company focused on developing precision medicines for MND and other neurodegenerative diseases, has announced the opening of a clinical trial in the UK. This trial of a gene therapy, called QRL-201, is a phase 1 trial in people with MND and will test the therapy to determine whether it is safe and…

Harnessing the power of plants

17 August 202317 August 2023Mandy Spencer

Reading Time: 12 minutes Despite decades of research, we still do not fully understand why some people get MND, but studies in cell and animal models of the disease suggest that astrocytes and microglia cells are key players in the process, and a potential target for new therapies to moderate oxidative stress, reduce mitochondrial damage, and limit glutamate excitotoxicity…

Could MND be caused by a virus? A new clinical trial investigates

15 June 202316 June 2023Research Development Team

Reading Time: 6 minutes MND is a complex disease, and the causes are still not fully understood. Researchers all around the world are working tirelessly on different theories to try to understand more about what causes MND and how to treat it. One theory is that MND is caused by the activation of ancient viruses which are hidden within…

Making new models to study MND and Frontotemporal Dementia

7 June 20237 June 2023Research Development Team

Reading Time: 3 minutes Introduction A genetic change in the C9orf72 gene is the most common genetic cause of motor neurone disease (MND), accounting for 40%-50% of people with familial MND and 5%-10% of people with sporadic MND. This genetic change in C9orf72 can also lead to behavioural symptoms of frontotemporal dementia (FTD), in some people with MND (around…

SOD1 MND – searching for more clues in our genes

2 March 20236 March 2023Charlotte Roy

Reading Time: 2 minutes Researchers from King’s College London have recently completed a study looking into different variations (a change or mistake) within the SOD1 gene and found that understanding the position and type of change within the gene can help to predict onset and progression of the disease.

Building the MND Research Workforce

10 February 20236 March 2023Emma Williams

Reading Time: 4 minutes The exact causes of MND are still unknown and there remain gaps in knowledge which need filling to find effective treatments. It is like a puzzle with thousands of pieces: some big, some small and some still missing from the box. As decades of research have gone on, the bigger picture continues to become clearer.…

Driving research forward – £1 million awarded to research into cutting-edge therapies for MND

24 January 202327 January 2023Research Development Team

Reading Time: 4 minutes In 2021, the MND Association, the My Name’5 Doddie Foundation and medical research charity LifeArc established a joint fund – the Motor Neuron Disease Translational Fund – to support translational research in motor neurone disease. In January 2023, £1 million was awarded to researchers at University College London (UCL) to progress two promising new therapies,…

Could evidence of MND be found years before the development of physical symptoms?

26 October 202226 October 2022Research Development Team

Reading Time: 6 minutes A recent paper (October 2022), published in the journal Journal of Pathology: Clinical Research suggests that evidence of MND can be seen inside people years before they develop physical symptoms. The paper titled ‘pTDP-43 aggregates accumulate in non-central nervous system tissues prior to symptom onset in amyotrophic lateral sclerosis: a case series linking archival surgical biopsies…

Symposium Spotlight: CRISPR- the magic behind gene editing in MND

28 April 202229 April 2022Eleanor Green

Reading Time: 6 minutes As part of our Symposium Spotlight series, we’re looking back on some of the research presented at the 32nd International Symposium on ALS/MND. This blog takes a closer look at the Stephen Hawking Memorial Lecture (supported by The Stephen Hawking Foundation) which was presented by Professor Jennifer Doudna, a joint Nobel Prize winner for her…